Flow Chemistry
The modular design of the Contiplant system is based on Fluitec’s continuous mixer / heat exchangers. It allows each process to be developed quickly and precisely for the target product on a laboratory scale.
Contiplant – continuous reaction technology
Owing to the modular design of the Fluitec Contiplant system, it is now an easy matter to test the conversion from batch to continuous reaction processes and assess the economic impact. In many cases, significant business potential can be identified based on the higher concentrations, better temperature control or other process intensification measures. This potential can then be leveraged consistently when moving from the laboratory to the pilot plant due to the excellent heat transfer rate of the Fluitec Contiplant modules.
The achievement of full modularity results in a shorter and more straightforward design phase.
Contiplant PILOT rack with redundant reactors and residence time section
The Fluitec scale-up system
Our mixer / heat exchangers can be scaled up easily and accurately because a constant surface-to-volume ratio is maintained regardless of the size of the apparatus.
The design of the mixing elements is simultaneously adapted so that the local flow patterns – and hence the specific power – also remain constant. This is possible thanks to the various, complex mixer / heat exchanger generations.
Apparatus of different sizes but with an identical surface-to-volume ratio are defined along the scale-up lines, so that precise scale-ups can be realised very simply.
Fluitec scale-up concept
Reaction systems
Fluitec designs, builds and manufactures reaction systems. As a result of our highly specific know-how in the field of static mixers and mixer / heat exchangers, we focus on those parts of the system where media are mixed, reactions controlled, temperatures set or narrow residence times maintained.
Apart from simple tube reactor systems, Fluitec can also offer combinations with other reactor or process apparatus such as loop systems, CSTR or agitators.
Pilot-scale polymer plant
Fluitec reaction system for sterile applications in the pharmaceutical industry
Reaction systems sterile applications
Reaction systems in sterile design for the pharmaceutical, biotechnology or cosmetics industry are a speciality.
Fluitec in-line reaction systems in sterile technology are used for high requirements regarding GMP, surface quality, CIP/SIP and FDA.
If required, novel static mixing elements in polished design are used, which can be manufactured with high precision in the smallest nominal widths thanks to a manufacturing process developed in-house.
Materials: 1.4435, 1.4435 BN2, 1.4404, Hastelloy C-22, or other high-alloy grades.
Reaction calorimetry
The Fluitec Flow Calorimeter (FFC) is especially suitable to obtain thermodynamic information for a scale-up of continuous processes in tubular reactors. This is useful because the released heat can strongly depend on the reaction control, especially for non-selective reactions. With the Fluitec Flow Calorimeter an axial temperature profile along the tube reactor can be recorded and the specific heat of reaction can be determined by means of heat balances and segmental dynamic parameters.
Reaction calorimeter
Principle flow calorimetry
The system consists of a tubular reactor, dosing systems, preheaters, temperature sensors and flow meters. Already existing ContiplantLAB PFR tube reactors can be converted easily into continuous reaction calorimeters.
Continuous milli-scale reaction calorimeter
Simultaneous determination of enthalpy
Reaction Calorimetry in Continuous Flow Mod
Further information